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Pantoprazole (Protonix) is an inexpensive drug used to treat gastroesophageal reflux disease, inflammation of the esophagus, and Zollinger-Ellison syndrome. This drug is slightly more popular than comparable drugs. It is available in brand and generic form. Generic pantoprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of pantoprazole is around $8.84, 86% off the average retail price of $66.96 ...

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Drug Info

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What is Pantoprazole?

Commonly Used Brand Name(s)

Protonix
Therapeutic Classifications

Gastric Acid Secretion Inhibitor
Pharmacologic Classifications

Proton Pump Inhibitor

Overview

Pantoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus. This medicine may also be used to treat Zollinger-Ellison syndrome, a condition where the stomach produces too much acid.

Pantoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release tablet whole. Do not split, crush, or chew it. You may take the tablet with or without food.

For delayed-release oral suspension granules:

Applesauce method:

Open packet.
Mix the packet contents with 1 teaspoonful of applesauce. Do not mix with water, other liquids, or food.
Swallow the mixture at least 30 minutes before a meal. Take it within 10 minutes after you mix it.
Sip some water after you swallow the mixture. This will make sure all of the granules get all the way to your stomach.
Do not chew or crush the granules. Do not divide the packet contents to make smaller doses.

Apple juice method:

Open packet.
Mix the packet contents with 1 teaspoon of apple juice in a small cup or container.
Stir for 5 seconds (granules will not dissolve) and swallow it immediately or take it at least 30 minutes before a meal.
Rinse the container with apple juice to make sure you get all of the medicine. Swallow it immediately.
Do not chew or crush the granules. Do not divide the packet contents to make smaller doses.

Feeding tube:

Pour the packet contents in a 2-ounce (60 mL) catheter-tip syringe.
Clear any clogs from the feeding tube before you put this medicine mixture into the tube.
Add 10 mL of apple juice into the syringe. Gently tap or shake the barrel of the syringe to help rinse the syringe and tube.
Repeat with an additional 10 mL of apple juice. No granules should remain in the syringe.
Take this medicine at least 30 minutes before a meal.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.· Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib
Acalabrutinib
Amphetamine
Atazanavir
Benzphetamine
Bosutinib
Capecitabine
Cilostazol
Citalopram
Dacomitinib
Dasatinib
Dextroamphetamine
Erlotinib
Eslicarbazepine Acetate
Gefitinib
Ketoconazole

Acalabrutinib
Acalabrutinib
Amphetamine
Atazanavir
Benzphetamine
Bosutinib
Capecitabine
Cilostazol
Citalopram
Dacomitinib
Dasatinib
Dextroamphetamine
Erlotinib
Eslicarbazepine Acetate
Gefitinib
Ketoconazole

Side Effects

What should I watch for?

It can take several days before your stomach pain gets better. Check with your doctor or health care provider if your condition does not start to get better, or if it gets worse.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

You may need blood work done while you are taking this medicine.

This medicine may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care provider.

Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
Blurred vision
Dry mouth
Flushed, dry skin
Fruit-like breath odor
Increased hunger
Increased thirst
Increased urination
Nausea
Stomach pain
Sweating
Troubled breathing
Unexplained weight loss
Vomiting
Incidence not known
Absence of or decrease in body movements
Blindness
Blistering, peeling, or loosening of the skin
Bloating
Bloody or cloudy urine
Bloody, black, or tarry stools
Blurred vision
Chills
Clay-colored stools
Constipation
Continuous ringing or buzzing or other unexplained noise in the ears
Cough
Dark urine
Decreased vision
Diarrhea
Difficulty with speaking
Difficulty with swallowing
Dizziness or lightheadedness
Drowsiness
Fast heartbeat
Feeling of constant movement of self or surroundings

Fever
General feeling of tiredness or weakness
Greatly decreased frequency of urination or amount of urine
Headache
Hearing loss
High fever
Hives, itching, or skin rash
Indigestion
Joint pain
Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
Light-colored stools
Loss of appetite
Mood or mental changes
Muscle cramp, pain, or stiffness
Muscle spasms (tetany) or twitching
Pains in the stomach, side, or abdomen, possibly radiating to the back
Pale skin
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Red skin lesions, often with a purple center
Red, irritated eyes
Seizures
Sensation of spinning
Sore throat
Sores, ulcers, or white spots on the lips or in the mouth
Stomach pain, continuing
Swelling of the feet or lower legs
Swollen glands
Tightness in the chest
Trembling
Unexplained bleeding or bruising
Unpleasant breath odor
Unusual tiredness or weakness
Vomiting of blood
Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: